OptimalHealthNutrition.com -- NFKB modulation by diet

NFKB modulation by diet

Research News: I believe that future research will elucidate that the proposed anti-inflammatory benefits of plant-based diets[1] are partially resultant from the downregulation of NF-kappaB by dietary phytonutrients, of which more than 5,000 exist.[2] Notice that the above-mentioned suppressors of NF-kappaB are mostly phenolic compounds that are naturally occurring in fruits, vegetables, herbs, and spices. A diet based upon fruits and vegetables would be naturally high in these compounds and would be likely to provide an anti-inflammatory influence on genetic expression. Indeed, this dietary and phytonutritional environment would be consistent with that in which human physiology evolved, to which it adapted, and upon which it thereby became dependent.[3],[4] Relatedly, our epidemic of vitamin D deficiency[5] resultant from our artificial, indoor, clothed lifestyles unquestionably contributes to our modern pro-inflammatory tendency, and vitamin D supplementation has already proven to be immunomodulating and anti-inflammatory in human clinical trials.[6],[7],[8]

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[1] Seaman DR. The diet-induced proinflammatory state: a cause of chronic pain and other degenerative diseases? J Manipulative Physiol Ther. 2002;25(3):168-79

[2] "We propose that the additive and synergistic effects of phytochemicals in fruit and vegetables are responsible for their potent antioxidant and anticancer activities, and that the benefit of a diet rich in fruit and vegetables is attributed to the complex mixture of phytochemicals present in whole foods." Liu RH. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr. 2003 Sep;78(3 Suppl):517S-520S

[3] Heaney RP. Long-latency deficiency disease: insights from calcium and vitamin D. Am J Clin Nutr. 2003 Nov;78(5):912-9

[4] O'Keefe JH Jr, Cordain L. Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: how to become a 21st-century hunter-gatherer. Mayo Clin Proc. 2004 Jan;79(1):101-8

[5] Thomas MK, Lloyd-Jones DM, Thadhani RI, Shaw AC, Deraska DJ, Kitch BT, Vamvakas EC, Dick IM, Prince RL, Finkelstein JS. Hypovitaminosis D in medical inpatients. N Engl J Med. 1998 Mar 19;338(12):777-83

[6] Van den Berghe G, Van Roosbroeck D, Vanhove P, Wouters PJ, De Pourcq L, Bouillon R. Bone turnover in prolonged critical illness: effect of vitamin D. J Clin Endocrinol Metab. 2003 Oct;88(10):4623-32

[7] Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001 Nov 3;358(9292):1500-3

[8] Mahon BD, Gordon SA, Cruz J, Cosman F, Cantorna MT. Cytokine profile in patients with multiple sclerosis following vitamin D supplementation. J Neuroimmunol. 2003;134(1-2):128-32

Dr Vasquez's Comments: This is an excerpt from my textbook "Chiropractic and Naturopathic Mastery of Common Clinical Disorders" which is available from OptimalHealthResearch.com (website with clinical information designed for doctors) and also from OptimalHealthNutrition.com in our selection of books.

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