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LA
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Research News:
· linoleic acid, LA, 18:2n6, linoleate
o Essential fatty acid from nut, seed, and vegetable oils, especially safflower
oil, sunflower oil, corn oil, walnut oil, sesame seed oil, LA is the parent
fatty acid of the omega-6 class,
o EPA and DHA decrease conversion of linoleate to arachidonate; high doses of LA
inhibit conversion of alpha-LNA to EPA and DHA due to competition for delta-6
desaturase
o Hydrogenated “trans” forms are common in processed and fried foods,
o LA favors oxidative modification of LDL cholesterol, increases platelet
response to aggregation, and suppresses the immune system.[1] Adipose LA levels
are positively correlated with CVD.
o Promotes metastasis and inflammation.
o LA is the predominant PUFA in US diets. Daily intake of linoleic acid is
approximately 10 grams, only a small amount of which is converted to
arachidonate.[2]
o LA effectively lowers cholesterol, but otherwise this fatty acid is
consistently associated with exacerbation of cancer and inflammation and thus
should be avoided.
o LA undergoes oxidative metabolism by 15-lipoxygenase-1 to form 13-S-HODE[3],
and this is discussed in greater detail later in this section
--------------------------------------------------------------------------------
[1] Simopoulos AP. Essential fatty acids in health and chronic disease. Am J
Clin Nutr. 1999 Sep;70(3 Suppl):560S-569S
[2] Delvin TM. Textbook of Biochemistry with Clinical Correlations. New York:
Wiley-Liss, 1997. Pages 431-441
[3] Shureiqi I, Lippman SM. Lipoxygenase modulation to reverse carcinogenesis.
Cancer Res. 2001 Sep 1;61(17):6307-12
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Dr Vasquez's Comments:
This is an excerpt from my textbook "Chiropractic and Naturopathic
Mastery of Common Clinical Disorders" which is available from
OptimalHealthResearch.com
(website with clinical information designed for doctors) and also from
OptimalHealthNutrition.com
in our selection of books.
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