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GLA
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Research News:
· gamma (g)-linolenic acid, GLA, 18:3n6, gamma-linolenate
o Formation is increased from linoleic acid by vitamin C[1]
o Found in evening primrose oil, borage seed oil, hemp seed oil, and black
currant seed oil
o GLA restores action of delta-6-desaturase (D6D) in aging animals, suggesting
that GLA intake should increase in older rats and humans
o Useful in eczema for improvement in skin health and in diabetes especially for
improvement in nerve function
o GLA may facilitate the conversion of ALA to EPA and perhaps to DHA.
o In patients who respond to GLA supplementation, we can reasonably hypothesize
that they have impaired D-6-Desaturase activity since most patients have
adequate dietary intake of LA. Therefore, by extension, we can suppose that
their conversion of ALA to EPA is likewise impaired and that they may benefit
from EPA supplementation.
o Formation of GLA from LA is inhibited by EPA and other n-3 EFAs[2]
o Overall, the weight of the research suggests that supplementation with GLA
does lead to modest increases in arachidonate, despite the slow conversion of
DGLA to arachidonate by delta-5 desaturase. Coadministration of EPA with GLA
prevents any rise in arachidonate, as discussed later in this section.
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[1] Horrobin DF. Ascorbic acid and prostaglandin synthesis. Subcell Biochem
1996;25:109-15
[2] Horrobin DF. Interactions between n-3 and n-6 essential fatty acids (EFAs)
in the regulation of cardiovascular disorders and inflammation. Prostaglandins
Leukot Essent Fatty Acids 1991 Oct;44(2):127-31
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Dr Vasquez's Comments:
This is an excerpt from my textbook "Chiropractic and Naturopathic
Mastery of Common Clinical Disorders" which is available from
OptimalHealthResearch.com
(website with clinical information designed for doctors) and also from
OptimalHealthNutrition.com
in our selection of books.
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