 |
© Copyright 2008
Shopping cart software by Ecommerce Templates
|
|
|
|
DHA
|
Research News:
· DHA: docosahexaenoic acid, 22:6n-3
o Found only in plants of the sea, phytoplankton/microalgae, and consumers of
microalgae (such as fish)
o Essential for neural function, effectively absent in vegan diets, present in
breast milk (low in vegetarians); major n-3 in tissues; component of
phosphatidylethanolamine and phosphatidylserine; deficiency is associated with
inadequate intake of DHA and/or deficient conversion from ALA or EPA.
o Animal studies have shown that induction of DHA deficiency causes memory
deficits and a reduction in hippocampal cell size.[1]
o DHA is an important component of cell membranes and generally appears to
improve cell membrane function via improving receptor function and signal
transduction.
o DHA levels are reduced by ethanol consumption.[2]
o Animal studies suggest that vitamin B-6 deficiency can reduce the function of
delta-6-desaturase by 64% and lead to a reduction in EPA and DHA.[3]
o Supplementation with EPA+DHA is generally safe and reduces all-cause
mortality.[4]
In late 2003, bioactive metabolites of DHA were discovered. Previous to the
publication of this research, production of bioactive metabolites of DHA via
lipoxygenase and cyclooxygenase was unsuspected and/or unproved, and the
anti-inflammatory biochemical and clinical effects of DHA were mostly thought to
be due to alterations in membrane/receptor function and retroconversion to EPA.
We now know that DHA is converted by several mechanisms (lipoxygenase,
cyclooxygenase, random reactions, and cell-to-cell interactions) into
docosatrienes and resolvins
--------------------------------------------------------------------------------
[1] Ahmad A, Murthy M, Greiner RS, Moriguchi T, Salem N Jr. A decrease in cell
size accompanies a loss of docosahexaenoate in the rat hippocampus. Nutr
Neurosci. 2002 Apr;5(2):103-13
[2] Pawlosky RJ, Bacher J, Salem N Jr. Ethanol consumption alters
electroretinograms and depletes neural tissues of docosahexaenoic acid in rhesus
monkeys: nutritional consequences of a low n-3 fatty acid diet. Alcohol Clin Exp
Res. 2001 Dec;25(12):1758-65
[3] Tsuge H, Hotta N, Hayakawa T. Effects of vitamin B-6 on (n-3)
polyunsaturated fatty acid metabolism. J Nutr. 2000 Feb;130(2S Suppl):333S-334S
[4] “The recent GISSI (Gruppo Italiano per lo Studio della Sopravvivenza
nell'Infarto miocardico)-Prevention study of 11,324 patients showed a 45%
decrease in risk of sudden cardiac death and a 20% reduction in all-cause
mortality in the group taking 850 mg/d of omega-3 fatty acids.” O'Keefe JH Jr,
Harris WS. From Inuit to implementation: omega-3 fatty acids come of age. Mayo
Clin Proc. 2000 Jun;75(6):607-14
|
|
Dr Vasquez's Comments:
This is an excerpt from my textbook "Chiropractic and Naturopathic
Mastery of Common Clinical Disorders" which is available from
OptimalHealthResearch.com
(website with clinical information designed for doctors) and also from
OptimalHealthNutrition.com
in our selection of books.
|
|
|
|
|
All Products | Browse
Items | Search Items |
Secure Ordering |
Customer Entrance |
eNews, Audio MP3 Videos & PodCasts |
About |
Site Contents |
Community Links | Consult Dr VasquezOptimalHealthNutrition.com provides information for patients and the general
public, while OptimalHealthResearch.com provides information for
medical/chiropractic/osteopathic/naturopathic students and doctors. These sites
are owned by Integrative and Biological Medicine Research and Consulting LLC
(IBMRC).
Copyright 2009 by IBMRC and/or Dr Alex Vasquez. All rights reserved. Use of this
site implies agreement with our Terms &
Agreements. Caution: Bee products may cause allergic reactions in some
people. Due to honey content, not recommended for children under two years of
age. These statements have not been evaluated by the Food & Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any
disease.
|
